Author CINN

The most innovative designers consciously reject the standard option box and cultivate an appetite for thinking wrong.

19

Nov 2018

Una visión del emprendimiento desde el CINN

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Mañana 20 de Noviembre a las 20h, el Director del CINN Prof. Ramón Torrecillas impartirá una conferencia en el Club de Prensa de La Nueva España (C/ Calvo Sotelo 7, Oviedo) bajo el título “Una visión del emprendimiento desde el CINN“. Esta charla forma parte del ciclo de conferencias organizadas por la Delegación del CSIC en Asturias.

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08

Nov 2018

Loss of 5hmC identifies a new type of aberrant DNA hypermethylation in glioma

Posted by / in Featured Publications, Latest CINN Publications, Publications 2018, Publications Nanomedicine, Publications Nanomedicine 2018 / No comments yet

Aberrant DNA hypermethylation is a hallmark of cancer although the underlying molecular mechanisms are still poorly understood. To study the possible role of 5-hydroxymethylcytosine (5hmC) in this process we analyzed the global and locus-specific genome-wide levels of 5hmC and 5-methylcytosine (5mC) in human primary samples from 12 non-tumoral brains and 53 gliomas. We found that the levels of 5hmC identified in non-tumoral samples were significantly reduced in gliomas. Strikingly, hypo-hydroxymethylation at 4627 (9.3%) CpG sites was associated with aberrant DNA hypermethylation and was strongly enriched in CpG island shores. The DNA regions containing these CpG sites were enriched in H3K4me2 and presented a different genuine chromatin signature to that characteristic of the genes classically aberrantly hypermethylated in cancer. As this 5mC gain is inversely correlated with loss of 5hmC and has not been identified with classical sodium bisulfite-based technologies, we conclude that our data identifies a novel 5hmC-dependent type of aberrant DNA hypermethylation in glioma.

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11

Oct 2018

The Nanotechnology Center attracts the interest from four companies

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The research teams of four firms from the biomedical and technological sectors will move to the facilities of the Nanomaterials and Nanotechnology Research Center Research Center (CINN) in El Entrego. These researchers will  form part of joint research groups (open labs) composed by scientists from the CINN and from the companies themselves that will develop innovative products targeted at different markets: antibacterial materials for sanitary equipment, electronic systems for automotive solar roofs, optical sensors for food quality control and special concretes for the construction of temporary houses used in areas affected by natural disasters or by migrations resulting from wars.

Full Article

Written by: Miguel A. Gutiérrez. La Nueva España. 30/09/2018

 

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