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NEW MATERIALS FOR ACTIVE AND HEALTHY AGEING

27

Sep 2018

Asturias leads a project to identify epigenetic biomarkers linked to thyroid cancer

Posted by / in Blog Health, Featured News, News Nanomedicine / No comments yet

Article published in El Comercio on 25th September 2018 with an overview of the project “Improvement of the diagnostic yield of fine needle cytology (FNAC) samples by the detection of DNA markers, and its application for the early diagnosis Thyroid Carcinoma” funded by the Spanish Association Against Cancer.

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02

Jul 2018

El CINN pide otro edificio tecnológico en El Entrego y se compromete a “llenarlo”

Posted by / in Blog Health, Featured News / No comments yet

El diario La Nueva España se hace eco de la propuesta del Centro de Investigación en Nanomateriales y Nanotecnología para la construcción de un nuevo edificio tecnológico en El Entrego donde se puedan alojar empresas del sector biotecnológico que ya han mostrado su interés en trasladar su actividad a un entorno próximo al CINN.

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06

Feb 2018

DNA methylation changes in human lung epithelia cells exposed to multi-walled carbon nanotubes

Posted by / in Blog Health, Featured Publications, Latest CINN Publications, Publications 2017, Publications Nanomedicine, Publications Nanomedicine 2017 / No comments yet

Humans are increasingly exposed to nanoparticles and, although many of their physiological effects have been described, the molecular mechanisms underlying them are still largely unknown. The present study aimed to determine the possible role of certain epigenetic mechanisms in the cellular response of human lung epithelial cells that are triggered by long-term exposure to titanium dioxide nanoparticles (TiO2NPs) and multi-walled carbon nanotubes (MWCNTs). The results showed that exposure to TiO2NPs had only minor effects on genome-wide DNA methylation. However, we identified 755 CpG sites showing consistent DNA hypomethylation in cells exposed to MWCNTs. These sites were mainly located at low density CpG regions and enhancers, and very frequently on the X chromosome. Our results thus suggest that long-term MWCNT exposure may have important effects on the epigenome.

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