Blog de Salud

Nuevos materiales para un envejecimiento activo y saludable

27

Sep 2018

Asturias lidera un proyecto para identificar biomarcadores epigenéticos asociados a cáncer de tiroides

Posted by / in Blog Salud, Noticias Destacadas, Noticias Nanomedicina / No comments yet

Artículo publicado en el diario El Comercio el día 25 de Septiembre en el que se describe el proyecto “Improvement of the diagnostic yield of fine needle cytology (FNAC) samples by the detection of DNA markers, and its application for the early diagnosis Thyroid Carcinoma” financiado por la Asociación Española Contra el Cáncer.

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02

Jul 2018

El CINN pide otro edificio tecnológico en El Entrego y se compromete a “llenarlo”

Posted by / in Blog Salud, Noticias Destacadas / No comments yet

El diario La Nueva España se hace eco de la propuesta del Centro de Investigación en Nanomateriales y Nanotecnología para la construcción de un nuevo edificio tecnológico en El Entrego donde se puedan alojar empresas del sector biotecnológico que ya han mostrado su interés en trasladar su actividad a un entorno próximo al CINN.

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06

Feb 2018

DNA methylation changes in human lung epithelia cells exposed to multi-walled carbon nanotubes

Posted by / in Blog Salud, Publicaciones 2017, Publicaciones Destacadas, Publicaciones Nanomedicina, Publicaciones Nanomedicina 2017, Últimas Publicaciones CINN / No comments yet

Humans are increasingly exposed to nanoparticles and, although many of their physiological effects have been described, the molecular mechanisms underlying them are still largely unknown. The present study aimed to determine the possible role of certain epigenetic mechanisms in the cellular response of human lung epithelial cells that are triggered by long-term exposure to titanium dioxide nanoparticles (TiO2NPs) and multi-walled carbon nanotubes (MWCNTs). The results showed that exposure to TiO2NPs had only minor effects on genome-wide DNA methylation. However, we identified 755 CpG sites showing consistent DNA hypomethylation in cells exposed to MWCNTs. These sites were mainly located at low density CpG regions and enhancers, and very frequently on the X chromosome. Our results thus suggest that long-term MWCNT exposure may have important effects on the epigenome.

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