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FEATURED RESEARCH AND INSTITUTIONAL NEWS

10

May 2018

The Vice-president for International Relations of and the head of the Brussels Office of the CSIC visit the CINN

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The Vice-president for International Relations of the CSIC, Elena Dominguez and the head of the CSIC office in Brussels, Jorge Velasco, visited the CINN headquarters in El Entrego yesterday. Before visiting the CINN, they had the opportunity to also visit the facilities of Nanoker Research SL, a spin-off company of the CINN, which is specialized in the manufacturing of advanced ceramics and nanocomposites, and the Multifunctional Materials Development Unit located in Sotrondio where the CINN in collaboration with industrial companies perform the industrial upscaling of the materials previously developed at laboratory level.

 

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30

Apr 2018

Pint of Science Festival 2018

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The Pint of Science is an outreach event that brings science and technology to bars. The Festival continues to grow and this year 57 Spanish cities participate in this event that will take place simultaneously  from 14 to 16 May in 21 countries worldwide.

Two CINN’s researchers, Prof. Jaime Ferrer and Dr. Victor Manuel García-Suárez are taking part in this event with two talks about nanoelectronics and graphene:

14th May. 19:30h. “Nanoelectronics, the next revolution?”​. V.M García-Suarez

Venue: Allegro ma non troppo (Pub Hotel 40 Nudos) C/ De la Fruta, 9, Avilés​

16th May. 19:30h. “Graphene’s revolution​”. Jaime Ferrer

Venue: Savoy Calle Covadonga, 5, Gijón

For further information visit: https://pintofscience.es/

 

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10

Apr 2018

Talks “What do we know about…?”

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The cycle of talks “What do we know about…?” aims to serve as a new space for dialogue between the scientific community and society, a space in which the protagonists of science will explain scientific news, its processes and its impact on our daily lives, while also leaving time for debate.

In Asturias the cycle is coordinated by the regional CSIC’s delegation and the conferences will take place in the Club de Prensa de La Nueva España, Oviedo,  throughout the months of April-May-June.

Programme:

23 ABR. Manuel de León. Las matemáticas de la luz
8 MAY. Carmen Gil. El Parkinson
15 MAY. José Luis Fernández Barbón. Los límites del espacio y el tiempo
23 MAY. Susana Delgado. Los microorganismos de nuestro cuerpo y la microbiota humana
29 MAY. Miguel Herrero Las algas que comemos
12 JUN. José Ramón Alonso. El olfato

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09

Mar 2018

Round-Table: Women in Science

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The IES Pando in Oviedo organized this morning a round table to discuss about the role of Women in Science. Four scientists from the University of Oviedo and the Spanish Council for Scientific Research (CSIC) participated in this event:

  • Elena Arboleya García (University of Oviedo)
  • María Antonia López Antón (INCAR-CSIC)
  • Olga García-Moreno (CINN-University of Oviedo)
  • Lucía Riera Menéndez (CINN-CSIC)

The researchers shared their professional experiences with students and teachers, emphasizing the difficulties women have to face when pursuing a scientific career.

mesa redonda

 

 

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27

Feb 2018

The CINN attends the Big Science Business Forum 2018

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A delegation of the CINN is attending the Big Science Business Forum 2018. The conference takes place in Tivoli Congress Center in Copenhagen during 26-28 February, hosted by the Danish Ministry of Higher Education and Science and BigScience.dk. A 1000 delegates from more than 500 companies and organisations spanning approx. 30 countries have already registered.

The conference is arranged by the organisations CERN, EMBL, ESA, ESO, ESRF, ESS, European XFEL, F4E and ILL. A further nine Big Science organisations have joined the conference programme – ALBA, DESY, ELI-NP, ENEA, FAIR, MAX IV, SCK•CEN – MYRRHA, PSI and SKA – thereby gathering 18 of the world’s most advanced Big Science organisations under one roof.

For further information visit the conference website

big science forum_small

 

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30

Jan 2018

Insights into cancer evolution

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PRESS RELEASE

Until now, scientists have failed to establish a link between the properties of pancreatic cancer, such as its aggressiveness, and changes, i.e. mutations, in the tumor’s genome. Moreover, pancreatic cancer forms metastases much faster than other types of cancer. Here too, the genetic causes are unclear.
A team headed by Professor Roland Rad and Professor Dieter Saur of TUM University Hospital rechts der Isar and the German Cancer Consortium has taken an important step towards solving both mysteries. With the help of various mouse models for pancreatic cancer, they have succeeded in elucidating the molecular pathways of tumor development in detail and have gained a better understanding of how various characteristics of the disease arise.

Tumor cells have multiple defective copies of a cancer gene

Healthy cells in humans possess two copies of each gene. For their experiments, the researchers mutated one of the two copies of the KRAS gene in mice. The gene plays a key role in cellular proliferation and is activated in 90% of all human pancreatic tumors. Such genes are referred to as oncogenes. The team headed by Roland Rad made a surprising discovery: The mutant gene was often duplicated even in very early stages of the cancer. In cases where a tumor had not doubled the mutated KRAS gene copy, the researchers discovered duplications in other cancer genes.
“It therefore appears that the cell amplifies the growth signal due to the presence of extra gene copies. This model of dosage amplification during tumor development had not previously been considered,” says Sebastian Müller, lead author of the study. “We also showed that as the number of mutant KRAS copies increases, the tumor’s aggressiveness and ability to metastasize also increases.”

Disruption of endogenous protective mechanisms determines the evolution of the cancer

Normally, healthy cells have their own protective mechanisms to prevent mutations from accumulating. So how could the cells develop such dosage amplification without being prevented from doing so?
“This shows the importance of mouse models, which allow us to closely observe and experimentally review the extraordinarily complex processes of cancer development at the molecular level: from healthy cells to cancer precursors through to aggressive tumors and their spread to other organs,” Professor Dieter Saur explains.
After the KRAS mutation was induced by the researchers, other mutations in what are known as tumor suppressor genes developed. A healthy cell possesses a whole series of such protective genes to prevent cancer from developing. A significant finding by the team was that either the mutant KRAS gene or another cancer gene is amplified, depending on which tumor suppressor gene is affected and to what degree its function is impaired.

Key developmental stages explained

Only after the cell’s inbuilt protective mechanisms have been switched off and dosage amplification occurs does a tumor ultimately form. Which pathway the cell follows, and which genes are involved then largely determine the characteristics of a pancreatic tumor.
For the first time, the dosage amplification model allows us to identify genetic patterns that explain a tumor’s aggressiveness and metastasis. “We have indications that our discovery constitutes a fundamental principle in the development of tumors and plays an essential role in other cancers. We’re now investigating the extent to which these new insights into cancer biology can be used to develop new therapeutic strategies,” says Professor Roland Rad, explaining the team’s next research goals.

The following institutions contributed to the study: Technical University of Munich (Central Institute of Translational Cancer Research, Clinic and Policlinic for Internal Medicine II, Institute of Pathology), DKTK and DKZF Heidelberg; The Wellcome Trust Sanger Institute, Cambridge; Ludwig-Maximilians Universität (Anthropology & Human Genomics und Innere Medizin II des Klinikums Großhadern), Helmholtz Zentrum München (Research Unit Radiation Cytogenetics); Universidad de Oviedo (Bioquímica y Biología Molecular, IUOPA und CINN-CSIC), Instituto de Medicina Oncológica y Molecular de Asturias (IMOMA), Oviedo, University of Cambridge (Department of Veterinary Medicine), Instituto de Medicina Oncológica y Molecular de Asturias, Instituto de Biomedicina y Biotecnología de Cantabria.

Original publication

S. Mueller, T. Engleitner, R. Maresch, M. Zukowska, S. Lange, T. Kaltenbacher, B. Konukiewitz, R. Öllinger, M. Zwiebel, A. Strong, H.-Y. Yen, R. Banerjee, S. Louzada, B. Fu, B. Seidler, J. Götzfried, K. Schuck, Z. Hassan, A. Arbeiter, N. Schönhuber, S. Klein, C. Veltkamp, M. Friedrich, L. Rad, M. Barenboim, C. Ziegenhain, J. Hess, O. M. Dovey, S. Eser, S. Parekh, F. Constantino-Casas, J. de la Rosa, M. I. Sierra, M. Fraga, J. Mayerle, G. Klöppel, J. Cadiñanos, P. Liu, G. Vassiliou, W. Weichert, K. Steiger, W. Enard, R. M. Schmid, F. Yang, K. Unger, G. Schneider, I. Varela, A. Bradley, D. Saur, R. Rad, Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes. 2017,

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21

Jun 2017

Microstructural study of Co-based superalloys and ODS steels obtained by Spark Plasma Sintering (SPS)

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The CINN has collaborated with IMDEA Materiales and the University Carlos III in the microstructural study of Co-based superalloys and ferritic ODS steels consolidated by Spark Plasma Sintering. The results of these studies were presented as oral presentations in the VI edition of the National Congress of Pulvimetallurgy that took place in Ciudad Real (Spain) from 7th to 9th June 2017.

The abstracts of the two lectures given are shown below:

Microstructural study of a group 4 (Y-Al-Ti-Zr) ODS ferritic steel consolidated by Spark Plasma Sintering (SPS).

E.Macía1, J.Cornide1, A-García-Junceda2, L.A. Díaz3, M. Campos1.

1 UNIVERSIDAD CARLOS III

2 IMDEA Materiales

3 CENTRO DE INVESTIGACIÓN EN NANOMATERIALES Y NANOTECNOLOGIA (CINN)

Oxide Dispersion Strengthened (ODS) ferritic Steels are extraordinary candidates for nuclear applications due to their good behavior at high temperature and under irradiation conditions .ODS ferritic steel was produced by mechanical alloying and SPS to obtain a complex nanostructure. A four group elements (Y-Ti-Al-Zr) was selected to improve the stability of the precipitates since they are the main responsible for the thermal stability of fine structure. The heterogeneous distribution of stored energy due to the high energy attrition of MA powder will produce an inhomogeneous recrystallization during the consolidation step. After SPS consolidation a heterogeneous grain size distribution was attained, as recrystallization depends on the plastic deformation degree, on the composition of each particle and on the oxide dispersion promoted. Therefore sintering cycle was performed at 1373 K following fast heating rates (from 100 to 600 °C/min) to minimize porosity. The final microstructures were characterized by XRD and electron microscopy (SEM and TEM). In addition, Vickers microhardness and tensile tests was performed to analyze the mechanical response at R.T.

Microstructural study of Co-9Al-9W alloys produced by SPS with Ti and Ta as alloying elementsEstudio microestructural de aleaciones de Co-9Al-9W producidas por SPS con Ti y Ta como aleantes

Marta Cartón-Cordero1 , Mónica Campos2 , Eric Macia-Rodríguez2 , Luis Antonio Díaz, 3 Jesús Cano-Cabello2 , Andrea García-Junceda1 , José M. Torralba2

1 IMDEA Materiales

2 UNIVERSIDAD CARLOS III

3 CENTRO DE INVESTIGACIÓN EN NANOMATERIALES Y NANOTECNOLOGIA

Co-based superalloys with ϒ-ϒ dual phase microstructure are considered a good alternative for high temperature in extreme environmental conditions applications due to their good strength, wear behavior and high oxidation resistance. In this work a fully prealloyed gas atomized powder with the nominal composition of Co-9Al-9W (at%) has been used. With the aim of promoting the ϒ´ phase precipitate, 2 at% of Ti and 2 at% of Ta have been added through mechanical alloying to the original powder. In order to reach a high level of densification maintaining an ultrafine grain size in the microstructure, the powder has been consolidated through Spark Plasma Sintering (SPS). The ϒ´ phase precipitate is obtained after subsequent heat treatments, first a solution treatment and then aging. By X ray diffraction (XRD) technique and scanning and transmission electron microscopy (SEM/TEM), the structural and microstructural changes produced after the heat treatments from the as obtained material have been monitored. The addition of Ti and Ta to the base alloy improves the ϒ’ phase precipitation process, and also affect to its thermal stability, improving the high temperature performance of the alloy. To characterize this influence on the ϒ´solution temperature, a thermo-gravimetric analysis has been performed for different compositions and heat treatments.

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15

Jun 2017

NASA and CINN plan to send mice to International Space Station

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News published in La Nueva España on 21st May 2017

The Nanomaterials and Nanotechnology Research Center (CINN) will study bone mass loss and other microgravity effects suffered by mice sent to Space. The Nanomedicine group of the CINN, led by Dr. Mario Fernández Fraga, takes part in a NASA research project aiming at the study of the human long-time exposure to microgravity and particularly the effect of such microgravity on bone development and disesases like arthritis or osteoporosis….

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16

May 2017

Talk on Nanomaterials at the Chelsea Café Lounge-Pint of Science

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On Wednesday 17 May, Prof. Ramón Torrecillas is giving a talk on Nanomaterials at Chelsea Café Lounge in Oviedo. This talk is part of the 3rd edition of the Pint of Science Festival that takes place over three days (15th-17th May) simultaneously in bars and pubs across eleven countries. This festival aims to make science accessible and fun by bringing current scientific research to the welcoming atmosphere of the bar.

For further information visit the Pint of Science website

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